Recent Publications

1.  Zhang, Z., Wang, Y., Vikis, H.G., Johnson, L., Anderson, MW., Sills, RC., Devereux, TR., Jacks,  T.,  Guan, KL., and You, M. Wild-Type K-Ras Can Inhibit Lung Carcinogenesis in Mice. Nature Genetics, 29:25-33, 2001.

2. Wang, Y., Hu, L., Yao, R., Crist, KA., Grubbs, GJ., Lubet, RA., You, M. Gene Expression Profile in Chemically Induced Rat Mammary Adenocarcinomas. Oncogene, 20:7710-7721, 2001.

3. Yao, R., Wang, Y., and You, M. Chromosomal mapping and sequence variation of the murine Nore1 Ras effector gene. Cytogenetics and Cell Genetics, 95:126-128, 2001.

4. Pohlod-Miller, S., Fanning, J., Gu, P., Crist, K.A., and You, M. Detection of Genomic Alterations in Human Endometrial Cancer by Two-Dimensional Gel Electrophoresis. Am. J. Obstet. & Gynecol., 186(5 Pt 1):855-857, 2002.

5. McDoniels-Silvers, A.L., Stoner, G.D., Lubet. R.A., and You, M. Differential Expression of Critical Cellular Genes in Human Lung Adenocarcinomas and Squamous Cell Carcinomas in Comparison to Normal Lung Tissues. Neoplasia, 4:141-150, 2002.

6. McDoniels-Silvers, A.L., Nimri, C.F., Stoner, G.D., Lubet. R.A., and You, M. Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas. Clinical Cancer Research, 8:1127-1138, 2002.

7. Yao, R., Wang, Y., Lubet, R.A., You, M. Differentially expressed genes associated with mouse lung tumor progression. Oncogene, 21:5814-5821, 2002.

8. Zhang, Z., Li, L., Lantry, L.E., Wang, Y., Wiseman, R.W., Lubet, R.A., and You, M. p53 transgenic mice are highly susceptible to carcinogen-induced uterine sarcomas. Cancer Res., 62:3024-3029, 2002.

9. William J Lemon, Heike Benert, Hao Sun, Yian Wang, and Ming You Identification of candidate lung cancer susceptibility genes in mice using oligonucleotide arrays. J Med Genet, 39: 639-643, 2002.

10. Zhongqiu Zhang, Yian Wang, Christopher R. Herzog, Gongjie Liu, Han-Woong Lee, Ronald A. DePinho, and Ming You. A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression. Oncogene, 21:5960-5966, 2002.

11. Daolong Wang, William J. Lemon, Michael F. W. Festing, and Ming You. Linkage Disequilibrium Mapping of Novel Lung Tumor Susceptibility Quantitative Trait Loci in Mice. Oncogene, 21:6858-6865, 2002.

12. Christopher R. Herzog, Theodora Devereux, and Ming You. Carcinogenic-induction increases genome-wide loss of heterozygosity and alters the profile of allelic losses selected during mouse lung tumorigenesis. Cancer Res. 62:6424-6429, 2002.

13. Ruisheng Yao, Yian Wang, Ronald A. Lubet, and Ming You. Differential Gene Expression in Chemically Induced Mouse Lung Adenomas. Neoplasia, 5:41-52. 2003.

14. Silvio De Flora, Roumen M. Balansky, Francesco D’Agostini, Alberto Izzotti, Anna Camoirano, Carlo Bennicelli, Zhongqiu Zhang, Yian Wang, Ronald A. Lubet, and Ming You. Molecular Alterations and Lung Tumors in p53 Mutant Mice Exposed to Cigarette Smoke. Cancer Res, 63: 793-800, 2003.

15. Konstantin Christov, Amy Ikui, Anne Shilkaitis, Albert Green, Ruisheng Yao, Ming You, Clinton Grubbs, Vernon Steele, Ronald Lubet, I. Bernard Weinstein. Cell Proliferation, Apoptosis, and Expression of Cyclin D1 and Cyclin E as Potential Biomarkers in Tamoxifen-Treated Mammary Tumors. Breast Cancer Research and Treatment, 77:253-264, 2003.

16. Jie Li, Zhongqiu Zhang, Zunyan Dai, Christoph Plass, Carl Morrison, Marshall W. Anderson, Yian Wang, and Ming You. LOH of chromosome 12p correlates with Kras2 Mutation in Non-Small Cell Lung Cancer. Oncogene, 22:1243-1246, 2003.

17. Laurent L. Ozbun, Alfredo Martinez, Jerry Angdisen, Sarah           Umphress, Yang Kang, Min Wang, Ming You, and Sonia B. Jakowlew. Differentially Expressed Nucleolar TGF-bl Target (DENTT) in Mouse Developmental Dynamics , 226:491-511, 2003.

18. WJ Lemon, CH Swinton, M Wang , N Berbari, Y Wang, M You. SNP Analysis of Mouse Pulmonary Adenoma Susceptibility Loci 1-4 for Identification of Candidate Genes. J Med Genet, 40:e36(1-7), 2003.

19. Allison E. Bonner, William J. Lemon, and Ming You. Gene Expression Signatures Identify Novel Regulatory Pathways During Murine Lung Development: implications for lung tumorigenesis. J Med Genet, 40:408-417, 2003.

20. Zhongqiu Zhang, Yian Wang, Laura E. Lantry, Elizabeth Kastens, Gongjie Liu, Andrew D. Hamilton, Said M. Sebti, Nancy E. Kohl, Ronald A. Lubet, and Ming You. Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant negative p53 and/or heterozygous deletion of Ink4a/Arf. Oncogene, 22:6257-65.  2003.

21. Min Wang, William J. Lemon, Gongjie Liu, Yian Wang, Fuad A. Iraqi, Alvin M. Malkinson, and Ming You. Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines. Cancer Res.63:3317-3324, 2003.

22. Yian Wang, Zhongqiu Zhang, Elizabeth Kastens, Ronald A Lubet, Ming You. Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild type and mutant A/J mice. Cancer Res. 63: 4389-4395, 2003.

23. Jie Li, Zhongqiu Zhang, Zunyan Dai, Anthony P Popkie, Christoph Plass, Carl Morrison, Yian Wang, and Ming You. RASSF1A Promoter Methylation and Kras2 Mutations in Non-Small Cell Lung Cancer. Neoplasia, 5:362-6, 2003.

24. Heike Bernert, Kenji Sekikawa, Richard Radcliffe, Fuad Iraqi, Ming You and Alvin M. Malkinson. Tnfa and Il-10 deficiencies have contrasting effects on lung tumor susceptibility: Gender-dependent modulation of IL-10 haploinsufficiency. Molecular Carcinogenesis, 38:117-123, 2003.

25. William J. Lemon, S. Liyanarachchi, and Ming You. A high performance test of differential gene expression for oligonucleotide arrays. Genome Biology, 4:R67 (1-11), 2003.

26. Ronald A. Lubet, Zhongqiu Zhang, Yian Wang, and Ming You. Chemoprevention of lung cancer in transgenic mice. Chest, 125(5 Suppl):144S-7S 2004.

27. Qunmin Zhou, Kotil Rammonham, Shili Lin, Nikki Robinson, Ou Li, Xingluo Liu, Xue-feng Bai, Lisa Yin, Bruce Scarberry, Ming You, Kunliang Guan, Pan Zheng, and Yang Liu. 2CD24 is a significant modifier for risk and progression of multiple sclerosis in human. Proc. Natl. Acad. Sci., 100:15041-6, 2003.

28. Zhongqiu Zhang, Manabu Futamura, Haris G. Vikis, Min Wang, Jie Li, Yian Wang, Kun-Liang Guan, and Ming You. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Proc. Natl. Acad. Sci., 100:12642-12647, 2003.

29. Allison E. Bonner, William J. Lemon, Theodora R. Devereux, Ronald A. Lubet, and Ming You. Molecular profiling of mouse lung tumors: association with tumor progression, lung development and human lung adenocarcinomas. Oncogene, 23:1166-1176, 2004.

30. Wang Y, Zhang Z, Yan Y, Lemon WJ, LaRegina M, Morrison C, Lubet R, You M. A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility. Cancer Res. 64:1647-54, 2004.

31. Garbow JR, Zhang Z, You M. Detection of primary lung tumors in rodents by magnetic resonance imaging. Cancer Res, 64(8):2740-2, 2004.

32. Meyer AM, Dwyer-Nield LD, Hurteau GJ, Keith RL, O'Leary E, You M, Bonventre JV, Nemenoff RA, Malkinson AM. Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2. Carcinogenesis. 2004 Mar 19 [Epub ahead of print]

33. Herzog, C. R., Bodon, N., Pittman, B., You, M., Anderson, M. W., Maronpot, R. R., Massey, T. E. and Devereux, T. R. Carcinogen-specific targeting of chromosome 12 for loss of heterozygosity in mouse lung adenocarcinomas: Implications for chromosome instability induction and tumor progression. Oncogene, 23(17):3033-9, 2004.

34. Han SY, Iliopoulos D, Druck T, Guler G, Grubbs CJ, Pereira M, Zhang Z, You M, Lubet RA, Fong LY, Huebner K. CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors. Oncogene. 2004 Mar 8 [Epub ahead of print]

35. Wang M, Devereux TR, Vikis HG, McCulloch SD, Holliday W, Anna C, Wang Y, Bebenek K, Kunkel TA, Guan K, You M. Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Cancer Res. 2004 Mar 15;64(6):1924-31.

36. Zhang Z, Wang Y, Yao R, Li J, Yan Y, Regina ML, Lemon WL, Grubbs CJ, Lubet RA, You M. Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models. Oncogene, 23(21):3841-50, 2004.

37. Yao R, Wang Y, William J. Lemon, Ronald A. Lubet, and Ming You. Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions. Oncogene, 23:7746-7752, 2004.

38. Bonner AE, Yian Wang and Ming You. Gene Expression Profiling of Mouse Teratocarcinomas Uncovers Epigenetic Changes Associated with the Transformation of Mouse Embryonic Stem Cells. Neoplasia, 6:490–502, 2004.

39. Tommasi S, Dammann R, Zhang Z, Wang Y, Liu L, Tsark WM, Wilczynski SP, Li J, You M, Pfeifer GP. Tumor susceptibility of Rassf1a knockout mice. Cancer Res. 2005 65:92-8.

40. Wang M, Futamura M, Wang Y, You M. Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus. Oncogene. 2005 24:1958-63.

41. Lubet R, Wang Y, Zhang Z, You M. Mouse models incorporating alterations in the major tumor suppressor genes P53 and P16: their use in screening for potential carcinogens, developing further relevant mouse models, and screening for potential chemopreventive and chemotherapetutic agents.Exp Lung Res. 2005 31:117-33.

42. Wang M, Wang Y, You M. Identification of genetic polymorphisms through comparative DNA sequence analysis on the K-ras gene: implications for lung tumor susceptibility. Exp Lung Res. 2005 31:165-77.

43. Chen B, Wang Y, You M. Characterization of two protein-binding sites in the second intron of the mouse K-ras gene. Exp Lung Res. 2005 31:179-92.

44. Wang Y, Zhang Z, Lubet R, You M. Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf. Oncogene. 2005 24:3042-9.

45. Wang M, Wang Y, You M, Devereux TR. Analysis of the Par2 modifier of pulmonary adenoma formation in mice. Exp Lung Res. 2005 31:193-204.

46. Yao R, Wang Y, D'Agostini F, Izzotti A, Lubet RA, You M, De Flora S. K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke. Exp Lung Res. 2005 31:271-81.

47. Zhang Z, Yao R, Li J, Wang Y, Boone CW, Lubet RA, You M. Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53. Mol Cancer Res. 2005 3:563-74.

48. Wang Y, Zhang Z, Yao R, Jia D, Wang D, Lubet RA, You M. Prevention of lung cancer progression by bexarotene in mouse models. Oncogene. 25:1320-9, 2006.

49. Wang Y, Zhang Z, Lubet RA, You M. A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice. Oncogene, 25:1277-80, 2006.

50. Zhang Z, Wang Y, Yao R, Lubet RA, You M. p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer. Mol Cancer Res., 4:401-10, 2006.

51. Wang Y, Yao R, Maciag A, Grubbs CJ, Lubet RA, You M. Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide. Mol Cancer Ther. 5:1060-72, 2006.

52. Yan Y, Wang Y, Tan Q, Hara Y, Yun TK, Lubet RA, You M. Efficacy of Polyphenon E, Red Ginseng, and Rapamycin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice. Neoplasia, 8:52-8, 2006.

53. Lu Y, Yao R, Yan Y, Wang Y, Hara Y, Lubet RA, You M. A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice. Cancer Res. 66:1956-63, 2006.

54. Yao R, Wang Y, Lu Y, Lemon WJ, End DW, Grubbs CJ, Lubet RA, You M. Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets. Carcinogenesis, 27:1420-1431, 2006.

55. Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, Macdougald OA, You M, Williams BO, Guan KL. TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth. Cell. 2006;126:955-68.

56. Liu P, Wang Y, Vikis H, Maciag A, Wang D, Lu Y, Liu Y, You M. Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. Nat Genet. 2006; 38:888-95.

57. Yan Y, Lu Y, Wang M, Vikis H, Yao R, Wang Y, Lubet RA, You M. Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer. Mol Cancer Res. 2006; 4:971-81.

58. Wang M, Zhang Z, Zhang Z, Vikis H, Yan Y, Wang Y, You M. Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance. Cancer Res. 2007; 67:2508-16.

59. Wang M, Vikis HG, Wang Y, et al. Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1. Cancer Res. 2007; 67:93-9.

60. Vikis H, Sato M, James M, Wang D, Wang Y, et al. EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. Cancer Res. 2007: 67:4665-70.